THE USE OF GELATIN-ACACIA CO-PRECIPITATE (GELAC) IN THE FORMULATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM
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ABSTRACT
Gums find application in tablet formulation as binder because of their adhesive nature. Natural gums are promising biodegradable polymeric materials. The aim of this study was to prepare a gelatin and acacia co-precipitate (GelAc) to be used as a release retardant in the formulation of sustained release matrix Tablets of diclofenac sodium. Gelatin and acacia solution was precipitated in a ratio of 1:1 using acetone as the precipitating solvent. The dried product was size reduced and the physicochemical properties of the precipitate (GelAc) were evaluated with respect to micromeritics and Fourier Transform Infrared (FT-IR) spectroscopy. FT-IR of GelAc showed no interaction between GelAc and diclofenac. GelAc was used in varying percentages of (10 - 50 %) of the total weight of the Tablet formulation. The formulated tablets were analysed for uniformity of weight tablet thickness and diameter, crushing strength, disintegration time, friability and content uniformity. In-vitro drug release profile of diclofenac sodium from GelAc matrix tablets were also studied using Simulated Gastric Fluid (SGF) for the first two hours and Simulated Intestinal Fluid (SIF) for the next eight hours. Hydroxypropylmethylcellulose (HPMC) was used as a standard matrix to compare the sustaining action of GelAc as a drug retardant for diclofenac sodium. Result from this study showed a good yield of GelAc (92.39 %) from the Coprecipitation. GelAc also had good flow properties. The tablets produced passed the official test for Tablets and had a good content uniformity. Dissolution tests carried out showed that with an increase in GelAc concentration there was a reduction in release rate. GelAc sustained the release of diclofenac sodium for over ten hours. Tablet formulation G2 containing 20 % GelAc was considered the best as it gave the highest release co- efficient value (n) at 0.963.The result from this study shows that GelAc can be used to formulate sustained release tablets of diclofenac sodium.
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